As well as research into primary immunodeficiencies, it is also conducting research to identify molecular bases in cases of less serious combined immunodeficiencies that have not yet been characterised by exogenous analysis or high-performance sequencing techniques, next generation sequencing (NGS).

The group’s basic and clinical lines of research surround, above all, the fields of inflammation and repair, respiratory insufficiency and tissue hypoxia. These fields complement one another and are connected through the study of conditions such as asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, infections, transplants, pulmonary hypertension and sleep-related breathing disorders.

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The Neurovascular Disorders research group’s lines of research cover prevention, treatment and repair aspects, also working on the identification of biomarkers in the pathology.

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The group is working on understanding the mechanisms involved in renal physiopathology. One of its main lines of research is the role that androgens play. Another important part of the group’s efforts is the early detection of biomarkers for kidney dysfunction, with high performance proteomic analysis and blood and urine samples from patients transplanted under different immunosuppressant regimes.

The research group focuses on shedding light on the molecular mechanisms behind the neurone cell death that occurs in neurodegenerative diseases, with the aim of finding a cure for this group of neurological, debilitating and incurable disorders. A large part of the group’s work is on Parkinson's disease, a specific neurodegenerative disorder that is mainly characterised by the degeneration of a specific type of neurone that has been identified as automatically limiting a small area of the brain known as substantia nigra pars compacta, which produces the neurotransmitter dopamine.

The group directs its research towards possible gene therapy strategies for autoimmune and neurodegenerative disorders, especially those associated with ageing. This type of disorder affects the central nervous system (CNS), one of the current challenges in relation to their treatment. There are no effective treatments to cure these illnesses. They are complex and there is the added element of not being able to easily access the CNS and treat them with classic drugs.

The team’s main aims are to establish synergies between clinics and researchers in the field of musculoskeletal problems, to develop and improve medical and surgical approaches to reconstruction techniques in orthopaedic surgery. This is reflected in lines of research for the study of neuromuscular pathology, paediatric musculoskeletal research, traumatic injuries, septic pathology (articular periprosthetic infection and osteomyelitis) and knee pathology.

This group’s lines of research  include investigation into biomaterials and bioengineering in surgery, with particular attention on the abdominal wall, colorectal, endocrine, bariatric and metabolic surgery, as well as thoracic surgery. 

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